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December 30th 2002

DNA Sequencing Helps Researchers Become First to Prove Same Protozoan Affects Both Humans and Swans

History-making find also discovers that swans show a spontaneous remission upon removal of cysts caused by the protozoan

Index to The Regal Swan Project

 Two English Mute Swans take a casual nap

Two English Mute Swans take a casual nap along the shores of Lake
Morton located in Lakeland, Florida. Lake Morton is a 40-acre natural
spring-fed lake located near downtown Lakeland.
Lakeland, Florida.
Photo By Rebecca Webb Wilson©. All rights Reserved. The Regal Swan™

Orlando, Florida

Six Florida researchers working with a Michigan State University associate professor and a medical mycologist from the Centers for Disease Control and Prevention in Atlanta, Georgia have become the first to prove that rhinosporidiosis in swans is the same protozoan affecting both humans and other animals.
   Dr. Geoffrey R. Gardner, a Lakeland veterinarian and researcher with the The Regal Swan™ team, removed eye cysts caused by the protozoan, Rhinosporidium seeberi, from 41 infected swans at Lake Morton in Lakeland, Florida. Dr. Leonel Mendoza, an associate professor with the Medical Technology Program, in the Department of Microbiology and Molecular Genetics from Michigan State University and Dr. Libero Ajello, a medical mycologist in the Mycotic Diseases Branch of the Centers for Disease Control, utilized DNA sequencing analysis to determine the genetic makeup of the protozoan.

Dr. Leonel Mendoza

Dr. Leonel Mendoza

Dr. Libero Ajello

Dr. Libero Ajello

DNA taken from the eye cysts of the swans was subsequently examined and tested with DNA from cysts with rhinosporidiosis taken from humans. The DNA analysis revealed the R. seeberi in both species is the same species.
   This find is historically important. Rhinosporidiosis, once thought to be caused by a fungus is now proven to be a protozoan. This organism is found in moist, warm environments and is most prevalent in India, Sri Lanka and southeast Asia, although cases have occurred in Africa, Central and South America, Europe and the United States. This protozoan has never been cultured and its natural habitat remained unknown.
   Rhinosporidium seeberi is a natural occurring micro-organism that infects the mucus surfaces of humans and animals who come into contact with it. Rhinosporidiosis is a byproduct of the micro-organism. It's a non-contagious chronic infection that usually manifests itself in the form of slow-growing-tumor-like masses that affect the nasal passages or the eyes. Currently, surgical removal is the only available treatment.
   However, this study showed that by surgically removing the cysts, the swans showed a spontaneous remission (no noted reoccurrence of the parasite). More testing is expected to be conducted by the doctors and The Regal Swan
researchers to find more information on this elusive parasite.
   The DNA testing was conducted in conjunction with a three-year study by The Regal Swan™ for a vaccine for botulism in swans. The group recently found that Pfizer's Ultrabac® CD is highly successful in combatting the deadly Clostridia bacterial toxin.

Researchers for The Regal Swan include: Geoffrey R. Gardner, D.V.M., Lakeland Veterinary Hospital, Lakeland, Florida; Christopher W. Brown, D.V.M., Central Florida relief veterinarian, Orlando, Florida; Fanchon F. Funk, Ed.D., associate professor, Florida State University, Tallahassee, Florida; Sheila A. Bolin, M.S., swan keeper, Orange Lake Resort & Country Club, Orlando, Florida; Rebecca Webb Wilson, J.D., professional photographer and lifetime trustee of the Memphis Zoological Society, Memphis, Tennessee; and Shirley A. Bolin, A.G.S., head photographer and staff writer, Orange Lake Resort & Country Club, Orlando, Florida.
In addition to working with Drs. Mendoza and Ajello, The Regal Swan
researchers have also been working closely with Her Majesty's Royal Swan Warden, Dr. Christopher Perrins, director of the Earl Grey Institute of Ornithology, Oxford University, London, England; and Her Majesty's Swan Marker, David Barber, London, England, during the three-year study conducted at Lake Morton, in Lakeland, Florida and Orange Lake Resort & Country Club, in Orlando, Florida.

English Mute Swans

 A pair of English Mute Swans on the banks of Orange Lake's Fountain Lake. The eight-acre lake is man made.
Photo By Shirley Bolin©. All rights Reserved. The Regal Swan™

Sponsors Include:
Pfizer Animal Health, Orange Lake Resort & Country Club, City of Lakeland, Florida, Lakeland Veterinarian Hospital, Antech Diagnostic Labs, Inc., American Camper, Blitz® USA, Bushnell Sports Optics Worldwide, Cobra Electronics, Hunt Manufacturing Company, Kaz Incorporated, Lab Essentials, Inc., The National High Magnetic Laboratory, Florida State University; The Memphis Zoo, Orlando Science Center, Thamesweb, Windsor, (Theroyalwindsorwebsite.com) England; Sharn Veterinary, Inc., The Sports Authority, Times®, VetCare, Vicks Company, IQ Scientific Instruments and Western Pest Services.

Swans at Orange Lake Resort

English Mute Swans reside at Orange Lake Resort & Country Club in Orlando, Florida.
Photo By Rebecca Webb Wilson©. All rights Reserved.
The Regal Swan™

Mute Swan's eye examined

An English Mute Swan's eye is examined for the cyst.
Photo By Rebecca Webb Wilson©. All rights reserved. The Regal Swan™.

Mute Swan's normal eye

An English Mute Swan's eye is normal in this photo.
Photo By Rebecca Webb Wilson©. All rights Reserved. The Regal Swan™

Rhinosporidium

Rhinosporidium
The cyst caused by the protozoan on an English Mute Swan's eye.
Photo By Shirley Bolin©. All rights Reserved. The Regal Swan™

English Mute Swan

An English Mute Swan surveys its surroundings on the Fountain Lake at
Orange Lake Resort & Country Club in Orlando, Florida.
Photo By Rebecca Webb Wilson©. All rights Reserved. The Regal Swan™

English Mute Swan

Lake Morton is home to more than 200 swans including English Mute Swans, Australian-Black Swans and South American Black-Necked Swans. The lake is also home to many other bird species including pelicans, geese, ducks, seagulls, egrets, blue herons and wood storks.
Photo By Shirley Bolin©. All rights Reserved. The Regal Swan™

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